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Jing Ma, Shiyu Chen, Lili Hao, Wei Sheng, Weicheng Chen, Xiaojing Ma, Bowen Zhang, Duan Ma, Guoying Huang
《医学前沿(英文)》 2021年 第15卷 第1期 页码 91-100 doi: 10.1007/s11684-020-0778-5
关键词: congenital heart disease Gene Expression Omnibus lncRNA SAP30-2:1 cell proliferation RNA immunoprecipitation HAND2
刘艳,黄鹏,孙晓如,林宁,喻荣彬,石慧,王丽娟
《中国工程科学》 2015年 第17卷 第6期 页码 41-44
探讨先天性心脏病与患儿母亲孕前及孕期环境因素暴露的关系。对先天性心脏病患儿的母亲面对面结构式访谈,填写调查问卷,共回收有效问卷373份,其中病例组157例,对照组216例。并分析孕前及孕期环境危险因素对胎儿先天性心脏病的影响。有先天性心脏病家族史、患儿母亲有流产史、不良妊娠史、孕期农药接触史、孕早期患病、孕早期用药、孕期胎儿异常与生育先天性心脏病患儿关系显著(P<0.05)。改善母亲健康状况,控制或减少工作生活环境中危险因素暴露,加强孕期检查,对于降低胎儿先天性心脏病发生风险尤为重要。
关键词: 胎儿;先天性心脏病;环境因素
林元,陈小玲,林晓文,刘敏,徐两蒲,何德钦,高丽素
《中国工程科学》 2014年 第16卷 第5期 页码 73-78
采用以院为基础的病例对照研究,在福建省妇幼保健院(三级甲等医院)募集新近发生的69 例胎儿先天性心脏病病例,以1∶1 配对的方法设立对照组,采用电感耦合等离子体质谱仪分析方法,测定病例组和对照组孕妇孕期头发中锑、锌、铜、铁、铅等元素的含量,并问卷调查孕早期危险因素的暴露情况,用SPSS19.0 Cox 比例风险模型进行流行病学多因素分析。孕妇发锑含量偏高(相对危险度的比值比(OR) =33.833;95 %可信区间(CI):4.060~281.929)、孕期使用不锈钢餐具(OR=8.981,95 % CI:1.085~74.327)、居所周围50 m有马路(OR=11.067,95 % CI:1.025~119.521)是先天性心脏病的危险因素。孕期锑负荷增加可能是先天性心脏病的原因之一。
贝叶斯推理和动态神经反馈促进先天性心脏病智能诊断的临床应用 Article
谭伟敏, 曹银银, 马晓静, 茹港徽, 李吉春, 张璟, 高燕, 杨佳伦, 黄国英, 颜波, 李健
《工程(英文)》 2023年 第23卷 第4期 页码 90-102 doi: 10.1016/j.eng.2022.10.015
先天性心脏病(CHD)是婴幼儿死亡的主要原因。基于人工智能的先天性心脏病诊断网络(CHDNet)是一种基于超声心动图视频的二分类模型,用于判别超声心动图视频是否包含心脏缺陷。现有的CHDNet模型表现出与医学专家相当甚至更好的判别性能,但它们在训练集之外的样本上的不可靠性已成为模型部署的关键瓶颈。而这是当前大多数基于AI 诊断方法的共性问题。为了克服这一挑战,本文提出了两种基本机制——贝叶斯推理和动态神经反馈——分别用于衡量和提高人工智能诊断的可靠性。贝叶斯推理允许神经网络模型输出CHD判别的可靠性而不仅仅是单一的判别结果,而动态神经反馈是一个计算神经反馈单元,允许神经网络将知识从输出层反馈给浅层,使神经网络有选择地激活相关神经元。为了评估这两种机制的有效性,我们在包含三种常见CHD 缺陷的4151 个超声心动图视频上训练了CHDNet,并在1037 个超声心动图视频的内部测试集和从其他心血管成像设备新收集的692 个外部视频集上对其进行了测试。每个超声心动图视频对应于一位患者和一次就诊。我们在多种代表性神经网络架构上展示了贝叶斯推理获得的可靠性如何解释和量化神经网络内部和外部测试集之间的性能显著差异,以及尽管输入被噪声破坏或使用外部测试集时,设计的反馈单元如何帮助神经网络保持高精度和可靠性。
Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 437-442 doi: 10.1007/s11684-009-0074-x
关键词: natriuretic peptide precursor A coronary heart disease gene polymorphism allelic discrimination polymorphism single nucleotide
Cluster analysis for syndromes of real-world coronary heart disease with angina pectoris
Yufeng Zhao, Xueyun Yu, Xinyu Cao, Lin Luo, Liyun He, Shusong Mao, Li Ma, Peijing Rong, Yuxue Zhao, Guozheng Li, Baoyan Liu
《医学前沿(英文)》 2018年 第12卷 第5期 页码 566-571 doi: 10.1007/s11684-017-0556-1
Syndromes of coronary heart disease with angina pectoris were analyzed to provide guidance for clinical practice and to improve accuracy of traditional Chinese medicine (TCM) diagnoses and efficacy of TCM treatment. A total of 860 cases with coronary heart disease with angina pectoris were selected from TCM Clinical Research Information Sharing System for TCM clinics and research. Syndromes were automatically extracted with the cluster method and were analyzed to provide objective evidence for clinical studies. Final syndrome classifications were recognized and confirmed by clinical experts. Popular syndromes included Qi and blood deficiency, blood stasis and obstruction collaterals, liver depression and spleen deficiency, and Qi stagnation and blood stasis. Syndromes Qi and blood deficiency and blood stasis and obstruction collaterals accounted for 28.61% of total syndromes, whereas liver depression and spleen deficiency and Qi stagnation and blood stasis accounted for 26.44%. The main syndrome elements comprised Qi deficiency, blood deficiency, blood stasis, and Qi stagnation.
关键词: syndrome differentiation real-world study coronary heart disease with angina pectoris cluster analysis
Advances in the management of the surgical complications for congenital cataract
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《医学前沿(英文)》 2012年 第6卷 第4期 页码 360-365 doi: 10.1007/s11684-012-0235-1
The greatest concern in children with cataracts is irreversible visual loss. The timing of congenital cataract surgery is critical for the visual rehabilitation. Cataract surgery in children remains complex and challenging. The incidence of complications during or after operation is higher in children than adults. Some complications could be avoided by meticulous attention to surgical technique and postoperative care, and others were caused by more exuberant inflammatory response associated with surgery on an immature eye or the intrinsic eyes abnormalities. Utilizing of advanced techniques and timely applying topical corticosteroids and cycloplegic agents can reduce the occurrence of visual axis opacification. Operation on children with strabismus or nystagmus, and applying occlusion therapy on amblyopic eyes can balance the visual inputs to the two eyes. Diagnosis of glaucoma following congenital cataract surgery requires lifelong surveillance and continuous assessment of the problem. So cataract surgeries in children are not the end of journey, but one step on the long road to visual rehabilitation. This paper describes recent evidence from the literature regarding the advance of management after congenital cataract surgery.
Caveolin proteins: a molecular insight into disease
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《医学前沿(英文)》 2016年 第10卷 第4期 页码 397-404 doi: 10.1007/s11684-016-0483-6
Caveolae are a kind of specific cystic structures of lipid rafts in the cytoplasmic membrane and are rich in cholesterol and sphingolipids. In recent years, many researchers have found that both caveolins and caveolae play a role in the development of various human diseases, including coronary heart disease, hypertension, and nervous system disorders. The specific mechanisms by which caveolins induce diseases have been a topic of interest. However, a number of detailed molecular mechanisms remain poorly understood. This article focuses on the relationship between caveolin proteins and human diseases and reviews the molecular mechanisms of caveolins in disease networks.
关键词: caveolin caveolae microRNA disease signaling pathway heart tumor
《医学前沿(英文)》 2023年 第17卷 第3期 页码 527-533 doi: 10.1007/s11684-022-0967-5
关键词: orthotopic heart transplant tricuspid regurgitation clinical impact biatrial heart transplantation
Histopathological study of congenital aortic valve malformations in 32 children
HUANG Ping, WANG Hongwei, LI Yanping, CHENG Peixuan, LIU Qingjun, ZHANG Zhenlu, LIU Jianying
《医学前沿(英文)》 2007年 第1卷 第1期 页码 74-78 doi: 10.1007/s11684-007-0015-5
《医学前沿(英文)》 2022年 第16卷 第2期 页码 295-305 doi: 10.1007/s11684-021-0857-2
关键词: chronic heart failure trimethylamine-N-oxide flavin monooxygenase 3 single nucleotide polymorphism
Applications of traditional pump design theory to artificial heart and CFD simulation
WANG Yingpeng, SONG Xinwei, YING Chuntong
《能源前沿(英文)》 2008年 第2卷 第4期 页码 504-507 doi: 10.1007/s11708-008-0059-5
关键词: computational high-efficiency artificial iterative approach artificial traditional
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《医学前沿(英文)》 2013年 第7卷 第3期 页码 301-305 doi: 10.1007/s11684-013-0283-1
Systemic inflammatory response following myocardial ischemia-reperfusion injury (IRI) to a specific organ may cause injuries. Ischemic post-conditioning (IPostC) has emerged as a promising method for myocardial protection against IRI both in experimental and in clinical settings. Enhancement of endogenous nitric oxide (NO) is one of the major mechanisms by which IPostC confers cardioprotection. However, the sensitivity of the diabetic heart to IPostC is impaired and the underlying mechanism is unknown. Adiponectin (APN) is an adipocyte-derived plasma protein with anti-diabetic and anti-inflammatory properties. Plasma levels of APN are decreased in obese subjects and in patients with type 2 diabetes. APN supplementation has been shown to increase NO production and attenuate myocardial IRI in normal (non-diabetic) animals. However, the effect of APN on myocardial injury in diabetic subjects, especially its potential in restoring the sensitivity of the diabetic heart to IPostC has not been investigated. In the current paper, we discussed the possible reasons why the myocardium of diabetic subjects loses sensitivity to IPostC and also highlighted the potential effectiveness and mechanism of APN in restoring IPostC cardioprotection in diabetes. This review proposes to conduct studies that may facilitate the development of novel and optimal therapies to enhance cardioprotection in patients with severe diseases such as diabetes.
关键词: adiponectin ischemic post-conditioning ischemia reperfusion injury diabetes
Hui Wang, Yang Zhang, Zhujun Shen, Ligang Fang, Zhenyu Liu, Shuyang Zhang
《医学前沿(英文)》 2021年 第15卷 第1期 页码 70-78 doi: 10.1007/s11684-020-0749-x
关键词: myocardial infarction percutaneous coronary intervention diabetes mellitus fasting glucose heart failure
ZHANG Kangkang, GU Enhua, LU Junjie
《医学前沿(英文)》 2008年 第2卷 第3期 页码 295-297 doi: 10.1007/s11684-008-0056-4
标题 作者 时间 类型 操作
Long non-coding RNA SAP30-2:1 is downregulated in congenital heart disease and regulates cell proliferation
Jing Ma, Shiyu Chen, Lili Hao, Wei Sheng, Weicheng Chen, Xiaojing Ma, Bowen Zhang, Duan Ma, Guoying Huang
期刊论文
The role of natriuretic peptide precursor A gene polymorphism in the development of coronary heart disease
Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,
期刊论文
Cluster analysis for syndromes of real-world coronary heart disease with angina pectoris
Yufeng Zhao, Xueyun Yu, Xinyu Cao, Lin Luo, Liyun He, Shusong Mao, Li Ma, Peijing Rong, Yuxue Zhao, Guozheng Li, Baoyan Liu
期刊论文
The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant
期刊论文
Histopathological study of congenital aortic valve malformations in 32 children
HUANG Ping, WANG Hongwei, LI Yanping, CHENG Peixuan, LIU Qingjun, ZHANG Zhenlu, LIU Jianying
期刊论文
FMO3--TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection
期刊论文
Applications of traditional pump design theory to artificial heart and CFD simulation
WANG Yingpeng, SONG Xinwei, YING Chuntong
期刊论文
Adiponectin: mechanisms and new therapeutic approaches for restoring diabetic heart sensitivity to ischemic
null
期刊论文
Prognostic value of fasting glucose on the risk of heart failure and left ventricular systolic dysfunction
Hui Wang, Yang Zhang, Zhujun Shen, Ligang Fang, Zhenyu Liu, Shuyang Zhang
期刊论文